Genetic susceptibility of mice to Candida albicans vaginitis correlates with host estrogen sensitivity.
نویسندگان
چکیده
We compared susceptibility to Candida vaginitis in derived murine substrains differing in sensitivity to estrogen (CD-1 and CD10, resistant; CD3 and C57BL/6 responsive), and in F1 crosses. The order of decreasing resistance was CD-1 > or = CD10 > or = CD10 x CD3F1 > CD10 x B6F1 > CD3 > C57BL/6 and correlated with estrogen responsiveness in endocrine disruptor assays. Resistance to Candida vaginitis appears additive in CD10 x B6F1 animals and dominant in CD10 x CD3F1 animals.
منابع مشابه
Differential susceptibility of two species of macaques to experimental vaginal candidiasis.
Vulvovaginal candidiasis (VVC) caused by Candida albicans is a significant problem in women of childbearing age. Unfortunately, protective host defense mechanisms against VVC are poorly understood. Although rodent models of experimental vaginal candidiasis have been useful, several differences from humans limit the correlation of experimental data. The purpose of the present study was to examin...
متن کاملEffects of preinduced Candida-specific systemic cell-mediated immunity on experimental vaginal candidiasis.
It has been postulated that systemic cell-mediated immunity (CMI) is an important host defense factor against recurrent vaginal infections caused by Candida albicans. Using an estrogen-dependent murine model of vaginal candidiasis, we have previously shown that mice inoculated vaginally with C. albicans acquire a persistent vaginal infection and develop Candida-specific Th1-type systemic CMI. I...
متن کاملIsolation, molecular identification, and antifungal susceptibility profiles of vaginal isolates of Candida species
BACKGROUND AND OBJECTIVES Vulvovaginal candidiasis is a common fungal infection among women during reproductive ages. Although, Candida albicans is accounted as the main etiologic agent of vaginitis, non-albicans species have arisen during last years. Resistant to antifungal drugs especially, fluconazole has been more reported by researchers from around the World. The aims of this study were to...
متن کاملStudy and detection of ERG11 gene mutation in resistant - drug Candida albicans and relation with Iranian women infertility
Aim and Background: Candida Albicans is the most important cause of vulvovaginal candidiasis and resistance to azoles can occur via various mechanisms including, change in the ERG11 gene. This study aim was to identification of ERG11 gene mutations in drug resistant Candida albicans isolated from patients with Candida vaginitis and its association with infertility in Iranian women. Mat...
متن کاملExtracellular Enzymes and Susceptibility to Fluconazole in Candida Strains Isolated From Patients With Vaginitis and Healthy Individuals
BACKGROUND Extracellular phospholipase, proteinase, and coagulase are accounted as the major virulence factors in Candida albicans. Several reports showed that the incidence of resistance to fluconazole has risen during last two decades. OBJECTIVES The present study has investigated the extracellular enzymes of C. albicans and non-albicans species isolated from both patients with vaginitis an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Infection and immunity
دوره 72 8 شماره
صفحات -
تاریخ انتشار 2004